Tifei Yuan's Lab
WHAT WE DO
The Yuan lab studies the plasticity change of neural circuits during addiction and depression. We mainly use animal electrophysiological records and neural circuit research, combined with human brain electrophysiological images and a variety of neural modulation techniques to explore changes in brain plasticity accompanying diseases. The experimental techniques we used include patch clamp electrophysiological recording of isolated brain slices, in vivo multichannel electrophysiological recording, optogenetics, histomorphology, single cell sequencing, behavior, non-invasive neural control techniques (TMS, tDCS, tACS), electroencephalography (EEG/ERP/TEP), brain imaging (MRI/PET), etc.
COME AND VISIT
The Yuan lab is located at the branch hospital of Shanghai Mental Health Center(SMHC, 3210 Hu Min Road, Minhang District, Shangai) . The divisions of the SMHC are as follows: The Shanghai Institute of Mental Health (SIMH), the Shanghai Psychotherapy and Psychological Counseling Center (SPCC), the Shanghai Municipal Clinical Center for Mental Disease, the National Institution for Clinical Drug Trials, the Shanghai Municipal Center of Mental Disease Prevention and Control (SCMDC), and the Shanghai Drug Abuse Treatment Center (SDATC).
Publications
Selected Publications
- Peng SY #, Shi Z #, Zhou DS #, Wang XY, Li XX, Liu XL, Wang WD, Lin GN, Pan BX, Voon V, Grace AA, Heilig M, Wong ML, Yuan TF * (2021) Reduced motor cortex GABABR function following chronic alcohol exposure. Mol Psychiatry 26: 383-395.
- Yuan TF *, Etkin A * (2021) Probing drug-evoked cortical plasticity with brain stimulation: A call for translation from animal to human medical research. Pharmacol Res. 163:105338
- Liu X #, Zhao X #, Liu T, Liu Q, Tang L, Zhang H, Luo W *, Daskalakis ZJ, Yuan TF * (2020) The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder. EBioMedicine 56:102809.
- Liu X #, Zhao X #, Shen Y #, Liu T, Liu Q, Tang L, Zhang H, Luo W *, Yuan TF * (2020) The effects of DLPFC-targeted repetitive transcranial magnetic stimulation on craving in male methamphetamine patients. Clin Transl Med 10(2):e48.
- Niu L #, Guo Y #, Lin Z #, Shi Z, Bian T, Qi L, Meng L, Grace AA *, Zheng H *, Yuan TF * (2020) Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance. Sci China Life Sci. 63(9):1-9.
- Ma S #, Zhang C #, Yuan TF*, Steele D, Voon V, Sun B* (2020) Neurosurgical treatment for addiction: Lessons from an untold story in China and a path forward. National Science Review 7: 702-712.
- Yuan J *, Liu W, Liang Q, Cao X, Lucas MV, Yuan TF* (2020) Effect of low-frequency repetitive transcranial magnetic stimulation on impulse inhibition in abstinent patients with methamphetamine addiction: a randomized clinical trial. JAMA Netw Open 3(3):e200910.
- Zhang M #, Zhao D #, Zhang Z, Cao X, Yin L, Liu Y, Yuan TF*, Luo W * (2019) Time perception deficits and its dose-dependent effect in methamphetamine dependents with short-term abstinence. Science Advances 5: eaax6916.
- Lin J #, Liu X #, Li H, Yu L, Shen M, Lou Y, Xie S, Chen J, Zhang R *, Yuan TF* (2019) Chronic repetitive transcranial magnetic stimulation (rTMS) on sleeping quality and mood status in drug dependent male inpatients during abstinence. Sleep Med 58: 7-12.
- Huang Y, Xu Z, Xiong S, Sun F, Qin G, Hu G, Wang J, Zhao L, Liang YX, Wu T, Lu Z, Humayun MS, So KF, Pan Y, Li N, Yuan TF*, Rao Y*, Peng B* (2018) Repopulated microglia are solely derived from the proliferation of residual microglia after acute
- Liu T, Li Y, Shen Y, Liu X, Yuan TF*(2018) Gender does not matter: Add-on repetitive transcranial magnetic stimulation treatment for female methamphetamine dependents. Progress in neuro-psychopharmacology & biological psychiatry 92:70-75.
- Huang X, Chen YY, Shen Y, Cao X, Li A, Liu Q, Li Z, Zhang LB, Dai W, Tan T, Arias-Carrion O*, Xue YX*, Su H*, Yuan TF* (2017) Methamphetamine abuse impairs motor cortical plasticity and function. Mol Psychiatry 22(9):1274-1281.
- Liu Q, Shen Y, Cao X, Li Y, Chen Y, Yang W, Yuan TF*. Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine. Am J Addict 26(8):776-779.
- Shen Y, Cao X, Shan C, Dai W, Yuan TF*. Heroin Addiction Impairs Human Cortical Plasticity. Biol Psychiatry 81(7):e49-e50.
- Wang Y, Shen Y, Cao X, Shan C, Pan J, He H, Ma Y, Yuan TF*(2016) Transcranial direct current stimulation of the frontal-parietal-temporal area attenuates cue-induced craving for heroin. J Psychiatr Res 79:1-3.
- Yuan TF, Mameli M, O'Connor EC, Dey PN, Verpelli C, Sala C, Perez-Otano I, Lüscher C, Bellone C*（2013) Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. Neuron 80(4): 1025-38.
Laboratory Equipment
